Integrins in invasive growth

Integrins in invasive growth.

Integrins in invasive growth

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Integrins anchor the invasive machinery.

Cell invasion through the basement membrane, a process important for both development and disease pathogenesis, depends on an interplay of adhesive, force transducing, proteolytic, and chemotactic machineries. The mechanisms whereby these different processes are integrated on the cellular level have remained elusive. In this issue of Developmental Cell, Sherwood and coworkers now identify integ...

Integrins Are the Necessary Links to Hypertrophic Growth in Cardiomyocytes

To compensate for hemodynamic overload of the heart, an event which stretches the myocardium, growth and survival signaling are activated in cardiac muscle cells (cardiomyocytes). Integrins serve as the signaling receptors of cardiomyocytes responsible for mechanotransduction toward intracellular signaling. The main integrin heterodimers on the cardiomyocyte surface are α(5)β(1) and α(v)β(3), a...

Integrins in immunity.

A successful immune response depends on the capacity of immune cells to travel from one location in the body to another--these cells are rapid migrators, travelling at speeds of microm/minute. Their ability to penetrate into tissues and to make contacts with other cells depends chiefly on the beta2 integrin known as LFA-1. For this reason, we describe the control of its activity in some detail....